A large number of studies suggest that most dyslexic children exhibit multiple underlying audio- phonological, visuo-attentional and audio-visual deficits, that are simultaneously present to varying degrees, leading to a wide range of deficits in reading and spelling. The originality of this intervention is to propose a multimodal and multi-componential rehabilitation programme, using individualized and intensive training at home during 6 months. We assessed benefits of the protocol through a multicenter, longitudinal, randomized, crossover and clinical trial including 3 stages that lasted for a total duration of 16 months. An overall of 94 speech and language therapists and 144 dyslexic readers (aged around 8-13 years) participated in the study. In the first phase, participants received weekly speech therapy for two months. In the second phase, in addition to their weekly speech therapy sessions, they received three types of intensive computer- based interventions, audio-phonological, visuo-attentional and audio-visual, for two months each. In the third phase, intensive interventions were discontinued and weekly speech therapy sessions were continued for two months. At the end of the remediation protocol, the multimodal and multi- componential intensive intervention lead to significant improvement in reading efficiency, reading comprehension and spelling, compared with weekly speech therapy. In addition, a multiple-case analysis showed that 52% of participants were no longer deficient in reading. Our results highlight the effectiveness of intensive multimodal and multi-componential remediation protocol, and open up a new issue in the remediation of developmental dyslexia.