Simultaneous SEEG-MEG-EEG recordings Overcome the SEEG limited spatial sampling

authors

  • Gavaret Martine
  • Dubarry Anne-Sophie
  • Carron Romain
  • Bartolomei Fabrice
  • Trébuchon Agnès
  • Bénar Christian-George

keywords

  • Epilepsy
  • Source localization
  • MEG
  • EEG
  • SEEG

document type

ART

abstract

During presurgical evaluation of pharmacoresistant partial epilepsies, stereoelectroencephalography (SEEG) records interictal and ictal activities directly but is inherently limited in spatial sampling. In contrast, scalp-EEG and MEG are less sensitive but provide a global view on brain activity. Therefore, recording simultaneously these three modalities should provide a better understanding of the underlying brain sources by taking advantage of the different sensitivities of the three recording techniques. We performed trimodal EEG-MEG-SEEG recordings in a 19-year-old woman with pharmacoresistant cryptogenic posterior cortex epilepsy. Sub-continuous and highly focal spikes that were not visible at the surface were marked on SEEG by an epileptologist. Surface signals, MEG and scalp-EEG, were then averaged locked on SEEG spikes. MEG sources were reconstructed based on a moving dipole approach (Brainstorm software). This analysis revealed source within the left occipital pole, located posteriorly to the SEEG leads presenting the maximal number of spikes, in a region not explored by SEEG. In summary, simultaneous recordings provide a new framework for obtaining a view on brain signals that is both local and global, thereby overcoming the inherent SEEG limited spatial sampling.

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