Strengths and challenges of longitudinal non-human primate neuroimaging


  • Song Xiaowei
  • García-Saldivar Pamela
  • Kindred Nathan
  • Wang Yujiang
  • Merchant Hugo
  • Meguerditchian Adrien
  • Yang Yihong
  • Stein Elliot A
  • Bradberry Charles W
  • Hamed Suliann Ben
  • Jedema Hank P
  • Poirier Colline


  • Magnetic resonance imaging
  • Development
  • Ageing
  • Templates
  • Simulation
  • Non-human primate

document type



Longitudinal non-human primate neuroimaging has the potential to greatly enhance our understanding of primate brain structure and function. Here we describe its specific strengths, compared to both cross-sectional non-human primate neuroimaging and longitudinal human neuroimaging, but also its associated challenges. We elaborate on factors guiding the use of different analytical tools, subject-specific versus age-specific templates for analyses, and issues related to statistical power.

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